Prevalence of Hepatitis C among Thalassemic patients referring to Kerman university of medical sciences hospital No.1 in 1996
Vahidi AA, Taheri A, Nikian Y
This prospective case-control study was carried out to evaluate the prevalence of positive cases of anti-HCV Ab in 107 thalassemic patients and 107 children without any previous history of blood transfusion as a control group. ELISA generation II was used for serologic investigation and then positive cases were confirmed by RIBA generation I. The average age of thalassemic patients was 9.2±4.3 years and those of control group was 8.9±4.2 years. 45.1% of the case group and 39.2% of the control group were female and 54.9% of the case group and 60.8% of the control group were male. Anti-HCV Ab was positive in 22.4% of the thalassemic patients while there was no positive case in the control group and the difference was statistically significant (P<0.001). The average number of transfusions was 104±58.2 in anti-HCV Ab positive thalassemic patients and 85.3±50.6 in anti-HCV Ab negative patients and the difference was not statistically significant (P=0.126). According to the results of this study, the prevalence of contamination with HCV was zero in normal population of Kermanian children and 22.4% in thalassemic patients. Therefore screening of donated bloods for anti-HCV Ab in order to eliminate the contaminated bloods has a significant importance in preventing HCV transmission in highrisk group.
Keywords: Thalassemia, Hepatitis C, Anti-HCV Ab, Blood transfusion